![]() ![]() Domain A2 (approximately 5kDa in cholera toxin or heat labile enterotoxin) provides a linkage to the B subunit through the B subunit's central pore. Domain A1 (approximately 22kDa in cholera toxin or heat labile enterotoxins) is the part of the toxin responsible for its toxic effects. In general, the two domains of the A subunit, named A1 and A2, are linked by a. This region has not been confirmed for the other AB5 toxin families as yet. A subunit The A subunit of an AB5 toxin is the portion responsible for catalysis of specific targets.įor Shiga toxin family, the A subunit hosts a -sensitive region which gives out two fragmented domains when cleaved. Ribbon diagram of the B-subunit of the cholera toxin. The last protein unit is unique and is known as the A subunit. Five units are similar or identical in structure and they comprise the B subunit. Structure A complete AB5 toxin complex contains six protein units. Some symptoms caused by this toxin are a decrease in count in the blood or, an increase in count or, and cell damage. It is called a subtilase cytotoxin because its A subunit sequence is similar to that of a subtilase-like in. It produced by strains of STEC that do not have the (LEE), and is known to cause hemolytic-uremic syndrome (HUS). Main articles: and This family is also known as SubAB and was discovered during the 1990s. ![]()
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